Maat GKnowledge

      

HEALTH-e-CHILD PROJECT



Maat-GKnowledge, with the collaboration of the TKBG group (Jaume I University of Castellon), participates in the development of the project a Health-e-Child (Work Packages 5, 6, 7 and 14). The project starts in January 2006 and will involve 15 partner organisations lead by Siemens Medical Solutions in Germany and including partners from United Kingdom, Italy, France, Spain, Switzerland, Greece and Estonia.

The Health-e-Child project aims at developing an integrated healthcare platform for European Paediatrics, providing seamless integration of traditional and emerging sources of biomedical information. The long-term goal of the project is to provide uninhibited access to universal biomedical knowledge repositories for personalised and preventive healthcare, large-scale information-based biomedical research and training, and informed policy making.

The general objectives of Health-e-Child are the following:

  • To gain a comprehensive view of a child’s health by vertically integrating biomedical data, information, and knowledge, that spans the entire spectrum from genetic to clinical to epidemiological (view Figure 1).

  • To develop a biomedical information platform, supported by sophisticated and robust search, optimisation, and matching techniques for heterogeneous information, empowered by the Grid.

  • To build enabling tools and services on top of the Health-e-Child platform, that will lead to innovative and better healthcare solutions in Europe:

    • Integrated disease models exploiting all available information levels.

    • Database-guided biomedical decision support systems provisioning novel clinical practices and personalised healthcare for children.

    • Large-scale, cross-modality, and longitudinal information fusion and data mining for biomedical knowledge discovery.


Figure 1: Health-e-Child Architecture


Work Package 6

The main objective of WP6 is to deliver a set of semantically rich models for integrated biomedical data and knowledge representation for use in database-guided decision support systems for paediatric healthcare.The identified biomedical information sources cover six levels (vertical levels): molecular, cellular, tissue, organ, individual and population. Ontologies will define the formal conceptualisation of the domain knowledge. They will ensure the consistency of the design model used for the data integration and will form the basis for the medical knowledge management system. Let us emphasize that ontologies won’t define only the knowledge for the biomedical domain, but also the knowledge for the grid system, defining resources: hardware, software, services, information, and so on.

Figure 2 shows the situation of WP6 in the general system. Its role will be to assists applications connected to HeC Gateway with information about domain knowledge and grid knowledge.


Figure 2: Work Package 6 in Health-e-Child

Figure 3 represents the data flows for WP6. The main input will be the RAW data from hospitals, and by means of the integrator system the six vertical levels (global schema) will be defined and integrated.


Figure 3: Data Schema for WP6


Work in progress

Nowadays, there are two main research lines in the Temporal Knowledge Bases Group (Jaume I University of Castellon, and Maat G Knowledge, Valencia) that can be helpful for the HeC project:

  • Development of a view-based methodology for the collaborative development of ontologies, with an application perspective [1]. The system will be based on the ontology editor Protégé 2000 and the semi-structured database G [4].

  • Design an development of an architecture for semantic integration systems, extending the classic ANSI/SPARC architecture for databases (view Figure 4) [2, 3].


Figure 4: Layers of the proposed architecture


References

  1. E. Jiménez, R. Berlanga. “A Methodology for the Colaborative Development of Ontologies: an Aproach for Applications”. Technical Report, 2006.

  2. I. Sanz, J. M. Pérez, R. Berlanga. “Hacia una arquitectura de referencia para la integración semántica de información”. . En REDBD'2002: Taller sobre Integración Semántica de Fuentes de Datos Distribuidas y Heterogéneas. El Escorial (Madrid), Noviembre de 2002

  3. R. Volz. “External ontologies in the semantic web”. In Proc. of the 20th British National Conference on Databases (BNCOD), Coventry, UK, 07 2003

  4. E. Jiménez. G Backend - Import – Export Plugin for Protégé: http://www3.uji.es/~ejimenez/GProtegePlugin/